Smiling young men camping in a field

Different patients. Different needs.

For appropriate patients, it may be time to consider a switch to IXINITY®.

There are many reasons why patients may need to switch their factor IX treatment. See why these patients made the switch, and decide if IXINITY may be right for patients in your practice.

Nathan

The confident control Nathan needs

 

Nathan, severe hemophilia B

 

Nathan’s Factor IX History

Frequent bleeds
Multiple infusions to resolve bleeds
Lack of motivation/confidence to be active

 

“In the past, I felt somewhat shackled by what life was like with hemophilia. I’ve had a lot of bleeds. I was infusing a lot.”

Reasons for switching to IXINITY

  • Effective bleed control and prevention
  • High recovery allowed a dosing volume that worked for him1
  • Peak factor level control helps him plan infusions around challenging workout days1

“With IXINITY, I’m only infusing 4000 IU, which is great for me. It was higher in the past.”

  • Coverage to plan ahead and be more active
  • IXINITY is a standard half-life factor IX that fits his active lifestyle
  • No longer feels held back by his hemophilia—more willing to “jump in and go” because he’s confident that he’s covered with IXINITY

“I like that I can plan my infusions on days when I want to do more challenging workouts, but I don’t have to worry if I still want to do some activities the next day.”

  • Intrigued by the 24-hour half-life and bleed control with one infusion1*
  • Needing fewer infusions has made a difference

“With the 24-hour half-life of IXINITY, I don’t have to infuse as often. And when it comes to managing my hemophilia, even a small difference can be a big deal.”

In a clinical trial of IXINITY, 71% of bleeds were resolved with 1 infusion.1 The number of days between dosing may vary. Individual response may vary.

This information is based on Nathan’s experience. Different patients may have different results.

Marcus

The opportunity for Marcus to live actively

 

Marcus, severe hemophilia B

 

Marcus’ Factor IX History

Frequent bleeds
Lack of control
Limited activity/independence

 

“For the longest time, I wasn’t getting the bleed control I wanted. It just wasn’t happening.”

Reasons for switching to IXINITY

  • Independence to manage hemophilia on his own
  • Switching to IXINITY gave him the confidence to know he’s covered

“My mom had been taking care of my hemophilia since I was a baby. She’s excited that I can do it on my own now.”

  • Reason to believe
  • Because IXINITY resolves most bleeds with 1 infusion,1* Marcus now has the bleed control he wanted

“I was dealing with a pretty bad bleed, and it stopped after I used IXINITY. I knew I made the right choice.”

  • An active lifestyle
  • 24-hour terminal half-life1 gives him the bleed control he needs for his active, everyday lifestyle

“You really do have the chance to be healthy with IXINITY while managing your hemophilia. IXINITY works for me in that way, so I can go play basketball, and I know I’ll be okay because of how long it’s working in my body.”

In a clinical trial of IXINITY, 71% of bleeds were resolved with 1 infusion.1 The number of days between dosing may vary. Individual response may vary.

This information is based on Marcus’ experience. Different patients may have different results.

Joe

Reliable coverage means less stress for Joe

 

Joe, severe hemophilia B

 

Joe’s Factor IX History

Worried over lack of bleed control
Sedentary lifestyle
Fearful of surgical procedures

 

“In the past, although I was infusing regularly, I’d still have breakthrough bleeds.”

Reasons for switching to IXINITY

  • Confidence in coverage
  • Proven bleed prevention and control gave Joe the confidence he needed to go about his everyday life without having to worry when he wants to go on a hike or change a tire

“Overall, it really comes down to coverage for me. Coverage means I have one less thing to worry as much about, I can make plans, try different things, and know I can rely on IXINITY when I need it.”

  • Motivation to move
  • The 0.98 IU/dL mean incremental recovery and 24-hour half-life of IXINITY1 help Joe achieve peak factor levels when he needs them, so he doesn’t have to worry about if—or when—he’s covered

“I was sedentary for a long time, but since I’ve been on IXINITY, I’ve started going to the gym. For the first time in 20 years, I’m under 300 pounds, and I’m able to get out and enjoy being more active.”

  • Peace of mind for procedures
  • The demonstrated efficacy of IXINITY in perioperative management gave Joe the confidence to move ahead with surgery1*

“Honestly, having IXINITY on board helped me have a certain peace of mind in making the decision to get the surgeries done.”

IXINITY was rated as adequate or better in controlling hemostasis post surgery as assessed by the surgeon.1

This information is based on Joe’s experience. Different patients may have different results.

Felix

The positive experience Felix was seeking

 

Felix, severe hemophilia B

 

Felix’s Factor IX History

Unhappy with current treatment
Seeking bleed control coverage
Desire to make a difference

 

“Growing up with hemophilia was scary and hard sometimes.”

Reasons for switching to IXINITY

  • A confident outlook
  • The proven efficacy of IXINITY gave Felix confidence to go out and live his life

“With IXINITY, my confidence has really changed. It’s not just in theory for me. When I’m on IXINITY, I feel like I’m covered.”

  • Proven bleed control
  • 98% recovery and peak factor level flexibility1 support Felix’s desire for an active lifestyle

“I’ve been using IXINITY for about 7 months, and I’ve had 1 bleed. It was at a Ninja Warrior Gym, and it was totally self-induced.”

  • A common cause
  • The support and commitment of IXINITY representatives to the hemophilia community matched his own dedication and drive to make a difference

“Hemophilia gave me drive, direction, compassion, and a place to do something for somebody else. So the way Aptevo has dedicated themselves to the community makes me proud to have a relationship with them.”

This information is based on Felix’s experience. Different patients may have different results.

Joel

A turning point in Joel’s treatment

 

Joel, hemophilia B

 

Joel’s Factor IX History

Struggled finding factor support
Frustrated with stereotypes about women with hemophilia B
Experienced frequent mouth bleeds

 

“I’ve had bleeding issues since I was a child, but they became hard to ignore.”

Reasons for switching to IXINITY

  • Peace of mind
  • The IXINITY FREE trial marked a turning point for Joel to get the treatment she needs

“For most of my life, women were only considered to be carriers. We didn’t really ‘have’ hemophilia B. So having my own factor was a real breakthrough.”

  • A shift in the stereotype
  • The Aptevo commitment to women and validation of her condition created a fundamental life change for Joel

“When a company like Aptevo wants to include women and cares what our experience is like, it matters. They’re the only company to have ever engaged in a way that I feel added value to my life.”

  • Flexibility that fits
  • Joel can plan her infusions and dental procedures to get a good night’s sleep. Not waking up to spontaneous mouth bleeds made a difference thanks to the 24-hour half-life of IXINITY1

“I knew from past dental work that I would get serious mouth bleeds. But my experience using IXINITY before my dental surgery was really positive.”

This information is based on Joel’s experience. Different patients may have different results.

Explore more about IXINITY

Reference: 1. IXINITY [coagulation factor IX (recombinant)] prescribing information. Seattle, WA: Aptevo BioTherapeutics LLC; December 2018.