Pharmacokinetics - IXINITY - 0.98 recovery and peak factor levels for active patients

Clearance drives high total exposure to factor

The most robust pharmacokinetic parameter for factor treatment is clearance as it is calculated from the area under the curve (AUC), which shows how well therapeutic factor IX levels are maintained.¹

Factor IX available over time

IXINITY AUC demonstrates prolonged maintenance of therapeutic factor IX levels^3*

*The pharmacokinetics of IXINITY have been evaluated in 32 previously treated patients (PTPs) ≥12 years of age with severe to moderately severe hemophilia B.²

*The pharmacokinetics of IXINITY have been evaluated in 32 previously treated patients (PTPs) ≥12 years of age with severe to moderately severe hemophilia B.²

Get more factor IX on board after infusion

Higher recovery with IXINITY may mean more factor IX in the bloodstream

Hypothetical example:

Patient who weighs 75 kg with a desired factor IX increase of 50% and a baseline factor level of <1%^†

*The pharmacokinetics of IXINITY have been evaluated in 32 PTPs ≥12 years of age with severe to moderately severe hemophilia B.²

^†Description is not of an actual patient. Individual dose will vary.

Go low with IXINITY^® to keep factor IX coverage high

Clearance drives high total exposure to factor

IXINITY AUC demonstrates prolonged maintenance of therapeutic factor IX levels^3*

Get more factor IX on board after infusion

Higher recovery with IXINITY may mean more factor IX in the bloodstream

24Hour²

high standard
half-life

Go low with IXINITY® to keep factor IX coverage high

Clearance drives high total exposure to factor

IXINITY AUC demonstrates prolonged maintenance of therapeutic factor IX levels3*

Get more factor IX on board after infusion

Higher recovery with IXINITY may mean more factor IX in the bloodstream

24Hour2

high standardhalf-life

Go low with IXINITY^® to keep factor IX coverage high

IXINITY AUC demonstrates prolonged maintenance of therapeutic factor IX levels^3*

24Hour²

high standard
half-life