Clinical Cases in the Management of Hemophilia B

Welcome to Clinical Cases in the Management of Hemophilia B. Delve into patient cases inspired by the challenges clinicians see in practice. Learn from other experts on treatment approaches that may benefit specific patient types.

An active adolescent with sport- related bleeding >OPEN TO LEARN MORE

A woman with hemophilia and heavy menstrual bleeding >OPEN TO LEARN MORE

An adult patient transitioning from a sedentary to a more active lifestyle >OPEN TO LEARN MORE



  • Identify key issues in adolescents with sport-related bleeds
  • Recognize the zero-bleed goal for patients like Jason
  • Review the selection of IXINITY from data on reaching peak factor levels

“And in Jason, what we see is that he may have up to 48 hours where his factor level is less than that three percent, which is a trough goal to prevent bleeding.”

Presented by Danielle Nance, MD
Banner MD Anderson Cancer Center, Gilbert, Arizona  


  • Recognize and manage heavy menstrual bleeding in women with hemophilia B
  • Understand the potential consequences of menstrual bleeding in this population
  • Review the rationale for treatment at the first sign of bleeding

“Taylor is a carrier of the hemophilia B gene and with her bleeding rnanifestations is justified to be called a female with hemophilia B.”

Presented by Craig Kessler, MD
MedStar Health, Georgetown University, Washington, DC    

‘The peak factor activity levels decrease risk of bleeding, and in patients with hemophilia and hemophilia B that decreased bleeding translates into improvement in overall pain, and reduced bleeding events lead to improved performance of joints and activity levels”

Presented by Danielle Nance, MD
Banner MD Anderson Cancer Center, Gilbert, Arizona    


  • Recognize the value of PK parameters beyond trough levels, such as peak concentration and clearance, as important determinants of treatment efficacy
  • Recognize the benefit of reduced bleeding in helping patients with cardiovascular risk to make changes
  • Consider prophylactic treatment for patients seeking to be more active